Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds

Hagai Glasner, Sigalit Meker, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.

Original languageAmerican English
Pages (from-to)33-35
Number of pages3
JournalJournal of Organometallic Chemistry
Volume788
DOIs
StatePublished - 25 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

  • Cisplatin
  • Cytotoxicity
  • Metallodrugs
  • Phenolato ligands
  • Titanium(IV)

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