Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds

Hagai Glasner; Sigalit Meker; Edit Y. Tshuva

doi:10.1016/j.jorganchem.2015.04.023

Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds

Hagai Glasner
, Sigalit Meker
, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.

Original language	English
Pages (from-to)	33-35
Number of pages	3
Journal	Journal of Organometallic Chemistry
Volume	788
DOIs	https://doi.org/10.1016/j.jorganchem.2015.04.023
State	Published - 25 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Cisplatin
Cytotoxicity
Metallodrugs
Phenolato ligands
Titanium(IV)

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10.1016/j.jorganchem.2015.04.023

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title = "Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds",

abstract = "Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.",

keywords = "Cisplatin, Cytotoxicity, Metallodrugs, Phenolato ligands, Titanium(IV)",

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AU - Glasner, Hagai

AU - Meker, Sigalit

AU - Tshuva, Edit Y.

PY - 2015/4/25

Y1 - 2015/4/25

N2 - Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.

AB - Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.

KW - Cisplatin

KW - Cytotoxicity

KW - Metallodrugs

KW - Phenolato ligands

KW - Titanium(IV)

UR - https://www.scopus.com/pages/publications/84928902698

U2 - 10.1016/j.jorganchem.2015.04.023

DO - 10.1016/j.jorganchem.2015.04.023

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AN - SCOPUS:84928902698

SN - 0022-328X

VL - 788

SP - 33

EP - 35

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

ER -

Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds

Abstract

Bibliographical note

Keywords

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