CD studies on ribonuclease a - oligonucleotides interactions

M. D. White; M. Keren-zur; Y. Lapidot

doi:10.1093/nar/4.4.843

CD studies on ribonuclease a - oligonucleotides interactions

M. D. White^*, M. Keren-zur, Y. Lapidot

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The interaction of ApU, Aps⁴U, Aps⁴Up, ApAps⁴Up and Gps⁴U with RNase A was studied by CD difference spectroscopy. The use of 4-th1our1d1ne (s⁴U) containing oligonucleotides enables to distinguish between the interaction of the different components of the ligand with the enzyme. The mode of binding of the oligonucleotides to the enzyme is described. From this mode of binding it 1s explained why Aps⁴U, for example, inhibits RNase A, while s⁴UpA serves as a substrate.

Original language	English
Pages (from-to)	843-852
Number of pages	10
Journal	Nucleic Acids Research
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/nar/4.4.843
State	Published - Apr 1977

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CD studies on ribonuclease a - oligonucleotides interactions

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