CD44 involvement in autoimmune inflammations: The lesson to be learned from CD44-targeting by antibody or from knockout mice

David Naor*, Shlomo Nedvetzki, Marita Walmsley, Avner Yayon, Eva A. Turley, Ira Golan, Dan Caspi, Lora Eshkar Sebban, Yehiel Zick, Tali Garin, Dimitrios Karussis, Nathalie Assayag-Asherie, Itamar Raz, Lola Weiss, Shimon Slavin, Itshak Golan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

57 Scopus citations

Abstract

CD44 is a multistructural and multifunctional glycoprotein, the diversity of which is generated by alternative splicing. In this communication we review some aspects related to CD44 structure and function in experimental autoimmune inflammation, focusing on research performed in our own laboratory. We have found that CD44 targeting by antibody, passively injected into DBA/1 mice with collagen-induced arthritis (CIA) and NOD mice with type I diabetes or actively generated by CD44 cDNA vaccination of SJL/j mice with autoimmune encephalomyelitis, markedly reduced the pathological manifestations of these diseases by attenuating cell migration of the inflammatory cells and/or by their apoptotic killing. However, genetic deletion of CD44 by knockout technology enhanced the development of CIA because of molecular redundancy mediated by RHAMM (a receptor of hyaluronan-mediated motility). The mechanisms that stand behind these findings are discussed.

Original languageEnglish
Title of host publicationAutoimmunity, Part B Novel Applications of Basic Research
PublisherBlackwell Publishing Inc.
Pages233-247
Number of pages15
ISBN (Print)1573317098, 9781573317092
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Autoimmune diseases
  • CD168
  • CD44
  • Hyaluronan
  • Inflammation
  • Molecular redundancy

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