@inproceedings{60f899092237458cb40f1c979647c5a3,
title = "CD44 involvement in autoimmune inflammations: The lesson to be learned from CD44-targeting by antibody or from knockout mice",
abstract = "CD44 is a multistructural and multifunctional glycoprotein, the diversity of which is generated by alternative splicing. In this communication we review some aspects related to CD44 structure and function in experimental autoimmune inflammation, focusing on research performed in our own laboratory. We have found that CD44 targeting by antibody, passively injected into DBA/1 mice with collagen-induced arthritis (CIA) and NOD mice with type I diabetes or actively generated by CD44 cDNA vaccination of SJL/j mice with autoimmune encephalomyelitis, markedly reduced the pathological manifestations of these diseases by attenuating cell migration of the inflammatory cells and/or by their apoptotic killing. However, genetic deletion of CD44 by knockout technology enhanced the development of CIA because of molecular redundancy mediated by RHAMM (a receptor of hyaluronan-mediated motility). The mechanisms that stand behind these findings are discussed.",
keywords = "Autoimmune diseases, CD168, CD44, Hyaluronan, Inflammation, Molecular redundancy",
author = "David Naor and Shlomo Nedvetzki and Marita Walmsley and Avner Yayon and Turley, {Eva A.} and Ira Golan and Dan Caspi and Sebban, {Lora Eshkar} and Yehiel Zick and Tali Garin and Dimitrios Karussis and Nathalie Assayag-Asherie and Itamar Raz and Lola Weiss and Shimon Slavin and Itshak Golan",
year = "2007",
month = sep,
doi = "10.1196/annals.1423.025",
language = "אנגלית",
isbn = "1573317098",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "233--247",
booktitle = "Autoimmunity, Part B Novel Applications of Basic Research",
}