CD68 staining correlates with the size of residual mass but not with survival in classical Hodgkin lymphoma

Ariel Agur, Gail Amir, Ora Paltiel, Martine Klein, Eldad J. Dann, Hanoch Goldschmidt, Neta Goldschmidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The prognostic role of CD68 tumor-associated macrophages in classic Hodgkin lymphoma (cHL) remains controversial. We stained diagnostic biopsies and scored for CD68 using the PGM1 antibody among 98 consecutive patients with cHL from our center followed over a median of 45 months for progression-free survival (PFS). Among 79 patients we assessed interim and post-treatment positron emission tomography-computed tomography (PET-CT). Residual mass (RM) size was based on the greatest diameter of the largest mass seen in post-treatment imaging, and percent reduction was calculated by comparing RM size with its greatest pretreatment diameter. We found a significant association between CD68 positivity and absolute size of initial disease mass (p = 0.014) and residual mass at the end of therapy (p = 0.006) but no association was observed with interim PET-CT results or PFS. Our findings suggest that macrophages may influence tumor size by altering the microenvironment. This study does not support a prognostic role of CD68 positivity in predicting survival.

Original languageEnglish
Pages (from-to)1315-1319
Number of pages5
JournalLeukemia and Lymphoma
Volume56
Issue number5
DOIs
StatePublished - 1 May 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Informa UK, Ltd.

Keywords

  • CD68
  • Hodgkin
  • Macrophages
  • Prognosis
  • Residual mass

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