CD74 is a novel transcription regulator

Naama Gil-Yarom; Lihi Radomir; Lital Sever; Matthias P. Kramer; Hadas Lewinsky; Chamutal Bornstein; Ronnie Blecher-Gonen; Zohar Barnett-Itzhaki; Vita Mirkin; Gilgi Friedlander; Lev Shvidel; Yair Herishanu; Elias J. Lolis; Shirly Becker-Herman; Ido Amit; Idit Shachar

doi:10.1073/pnas.1612195114

CD74 is a novel transcription regulator

Naama Gil-Yarom, Lihi Radomir, Lital Sever, Matthias P. Kramer, Hadas Lewinsky, Chamutal Bornstein, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Vita Mirkin, Gilgi Friedlander, Lev Shvidel, Yair Herishanu, Elias J. Lolis, Shirly Becker-Herman, Ido Amit, Idit Shachar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. This process leads to regulation of expression of these genes. Our results suggest that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease.

Original language	English
Pages (from-to)	562-567
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	114
Issue number	3
DOIs	https://doi.org/10.1073/pnas.1612195114
State	Published - 17 Jan 2017
Externally published	Yes

Keywords

CD74
CLL
NF-κB
RUNX
Transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.1612195114

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Gil-Yarom, N., Radomir, L., Sever, L., Kramer, M. P., Lewinsky, H., Bornstein, C., Blecher-Gonen, R., Barnett-Itzhaki, Z., Mirkin, V., Friedlander, G., Shvidel, L., Herishanu, Y., Lolis, E. J., Becker-Herman, S., Amit, I., & Shachar, I. (2017). CD74 is a novel transcription regulator. Proceedings of the National Academy of Sciences of the United States of America, 114(3), 562-567. https://doi.org/10.1073/pnas.1612195114

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Gil-Yarom, N, Radomir, L, Sever, L, Kramer, MP, Lewinsky, H, Bornstein, C, Blecher-Gonen, R, Barnett-Itzhaki, Z, Mirkin, V, Friedlander, G, Shvidel, L, Herishanu, Y, Lolis, EJ, Becker-Herman, S, Amit, I & Shachar, I 2017, 'CD74 is a novel transcription regulator', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 3, pp. 562-567. https://doi.org/10.1073/pnas.1612195114

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AU - Gil-Yarom, Naama

AU - Radomir, Lihi

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AU - Kramer, Matthias P.

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AU - Bornstein, Chamutal

AU - Blecher-Gonen, Ronnie

AU - Barnett-Itzhaki, Zohar

AU - Mirkin, Vita

AU - Friedlander, Gilgi

AU - Shvidel, Lev

AU - Herishanu, Yair

AU - Lolis, Elias J.

AU - Becker-Herman, Shirly

AU - Amit, Ido

AU - Shachar, Idit

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CD74 is a novel transcription regulator

Abstract

Keywords

UN SDGs

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