CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

Paul D.P. Pharoah; Carla Oliveira; José Carlos Machado; Gisella Keller; Holger Vogelsang; Holger Laux; Karl Friedrich Becker; Heidi Hahn; Suzanne M. Paproski; Lindsay A. Brown; Carlos Caldas; David Huntsman

doi:10.1002/ijc.10590

CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

Paul D.P. Pharoah^*
, Carla Oliveira
, José Carlos Machado
, Gisella Keller
, Holger Vogelsang
, Holger Laux
, Karl Friedrich Becker
, Heidi Hahn
, Suzanne M. Paproski
, Lindsay A. Brown
, Carlos Caldas
, David Huntsman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH 1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffusetype histopathologic subgroups.

Original language	English
Pages (from-to)	196-197
Number of pages	2
Journal	International Journal of Cancer
Volume	101
Issue number	2
DOIs	https://doi.org/10.1002/ijc.10590
State	Published - 10 Sep 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CDH1
Polymorphism
Stomach cancer
Susceptibility

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10.1002/ijc.10590

Cite this

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title = "CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer",

abstract = "We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH 1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95\% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffusetype histopathologic subgroups.",

keywords = "CDH1, Polymorphism, Stomach cancer, Susceptibility",

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year = "2002",

month = sep,

day = "10",

doi = "10.1002/ijc.10590",

language = "אנגלית",

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T1 - CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

AU - Pharoah, Paul D.P.

AU - Oliveira, Carla

AU - Machado, José Carlos

AU - Keller, Gisella

AU - Vogelsang, Holger

AU - Laux, Holger

AU - Becker, Karl Friedrich

AU - Hahn, Heidi

AU - Paproski, Suzanne M.

AU - Brown, Lindsay A.

AU - Caldas, Carlos

AU - Huntsman, David

PY - 2002/9/10

Y1 - 2002/9/10

N2 - We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH 1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffusetype histopathologic subgroups.

AB - We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH 1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffusetype histopathologic subgroups.

KW - CDH1

KW - Polymorphism

KW - Stomach cancer

KW - Susceptibility

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EP - 197

JO - International Journal of Cancer

JF - International Journal of Cancer

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ER -

CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

Abstract

UN SDGs

Keywords

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