CEACAM1 Activation by CbpF-Expressing E. coli

Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J. Slade, Ofer Mandelboim, Gilad Bachrach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Recent studies on the oral, anaerobic, gram-negative bacterium Fusobacterium nucleatum revealed its presence and involvement in colorectal, esophageal and breast cancer. We previously demonstrated that F. nucleatum binds and activates the human inhibitory receptors TIGIT and CEACAM1 leading to inhibition of T and NK cell anti-tumor immunity. CEACAM1 was found to be bound and activated by the fusobacterial trimeric autotransporter adhesin CbpF. Here we report the generation of a recombinant E. coli expressing full-length CbpF that efficiently binds and activates CEACAM1.

Original languageAmerican English
Article number699015
JournalFrontiers in Cellular and Infection Microbiology
Volume11
DOIs
StatePublished - 29 Jul 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Shhadeh, Galaski, Alon-Maimon, Fahoum, Wiener, Slade, Mandelboim and Bachrach.

Keywords

  • CEACAM1
  • CbpF
  • F. nucleatum
  • NK cells
  • trimeric autotransporter adhesin

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