Cell-autonomous and non-cell-autonomous functions of caspase-8

Tehila Ben Moshe, Tae Bong Kang, Andrew Kovalenko, Hila Barash, Rinat Abramovitch, Eithan Galun, David Wallach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Cells in vivo do not act in isolation. Therefore, when attempting to predict the results of pharmaceutical modulation of the function of a protein, we must also take into account the non-cell-autonomous consequences of such modulation. Studies of caspase-8 initially indicated that it serves as the proximal enzyme in cellular self-destruction dictated through the extrinsic cell-death pathway. Later studies revealed that it also participates in mechanisms affecting cell growth and survival. This essay presents a brief account of a study indicating that, apart from functional changes that are cell autonomous, tissue-specific deletion of caspase-8 in mice also has non-cell-autonomous effects with consequences that might even be the opposite of the cell-autonomous ones.

Original languageAmerican English
Pages (from-to)209-217
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume19
Issue number3-4
DOIs
StatePublished - Jun 2008
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Dr. Irun Cohen for advice on the study of the role of caspase-8 expression in β-Langerhans cells in the development of diabetes in NOD mice, and to Dr. Steffen Jung for advice and help in studying the recovery of mice from L. monocytogenes infection. We thank for scientific editing. Work done in the laboratory of DW was supported in part by grants from Ares Trading S.A., Switzerland; a Center of Excellence Grant from the Flight Attendant Medical Research Institute (FAMRI); and the Kekst Family Center for Medical Genetics at The Weizmann Institute of Science.

Keywords

  • Apoptosis
  • Caspase-8
  • Cell-autonomous
  • TNF
  • Therapy

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