Cell-based reparative therapies for multiple sclerosis

Tamir Ben-Hur*, Nina Fainstein, Yossi Nishri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The strong rationale for cell-based therapy in multiple sclerosis is based on the ability of stem and precursor cells of neural and mesenchymal origin to attenuate neuroinflammation, to facilitate endogenous repair processes, and to participate directly in remyelination, if directed towards a myelin-forming fate. However, there are still major gaps in knowledge regarding induction of repair in chronic multiple sclerosis lesions, and whether transplanted cells can overcome the multiple environmental inhibitory factors which underlie the failure of endogenous repair. Major challenges in clinical translation include the determination of the optimal cellular platform, the route of cell delivery, and candidate patients for treatment.

Original languageAmerican English
Article number397
JournalCurrent Neurology and Neuroscience Reports
Volume13
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Cell-based reparative therapies
  • Immunomodulation
  • Multiple sclerosis
  • Regeneration
  • Remyelination
  • Stem cells

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