TY - JOUR
T1 - Cell-based reparative therapies for multiple sclerosis
AU - Ben-Hur, Tamir
AU - Fainstein, Nina
AU - Nishri, Yossi
PY - 2013/11
Y1 - 2013/11
N2 - The strong rationale for cell-based therapy in multiple sclerosis is based on the ability of stem and precursor cells of neural and mesenchymal origin to attenuate neuroinflammation, to facilitate endogenous repair processes, and to participate directly in remyelination, if directed towards a myelin-forming fate. However, there are still major gaps in knowledge regarding induction of repair in chronic multiple sclerosis lesions, and whether transplanted cells can overcome the multiple environmental inhibitory factors which underlie the failure of endogenous repair. Major challenges in clinical translation include the determination of the optimal cellular platform, the route of cell delivery, and candidate patients for treatment.
AB - The strong rationale for cell-based therapy in multiple sclerosis is based on the ability of stem and precursor cells of neural and mesenchymal origin to attenuate neuroinflammation, to facilitate endogenous repair processes, and to participate directly in remyelination, if directed towards a myelin-forming fate. However, there are still major gaps in knowledge regarding induction of repair in chronic multiple sclerosis lesions, and whether transplanted cells can overcome the multiple environmental inhibitory factors which underlie the failure of endogenous repair. Major challenges in clinical translation include the determination of the optimal cellular platform, the route of cell delivery, and candidate patients for treatment.
KW - Cell-based reparative therapies
KW - Immunomodulation
KW - Multiple sclerosis
KW - Regeneration
KW - Remyelination
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84893052732&partnerID=8YFLogxK
U2 - 10.1007/s11910-013-0397-5
DO - 10.1007/s11910-013-0397-5
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 24078453
AN - SCOPUS:84893052732
SN - 1528-4042
VL - 13
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
IS - 11
M1 - 397
ER -