TY - JOUR
T1 - Cell-Cell Signaling Proteobacterial LuxR Solos
T2 - a Treasure Trove of Subgroups Having Different Origins, Ligands, and Ecological Roles
AU - Bez, Cristina
AU - Geller, Alexander Martin
AU - Levy, Asaf
AU - Venturi, Vittorio
N1 - Publisher Copyright:
© 2023 Bez et al.
PY - 2023/4
Y1 - 2023/4
N2 - Many proteobacteria possess LuxR solos which are quorum sensing LuxR-type regulators that are not paired with a cognate LuxI-type synthase. LuxR solos have been implicated in intraspecies, interspecies, and interkingdom communication by sensing endogenous and exogenous acyl-homoserine lactones (AHLs) as well as non-AHL signals. LuxR solos are likely to play a major role in microbiome formation, shaping, and maintenance through many different cell-cell signaling mechanisms. This review intends to assess the different types and discuss the possible functional roles of the widespread family of LuxR solo regulators. In addition, an analysis of LuxR solo types and variability among the totality of publicly available proteobacterial genomes is presented. This highlights the importance of these proteins and will encourage scientists to mobilize and study them in order to increase our knowledge of novel cell-cell mechanisms that drive bacterial interactions in the context of complex bacterial communities.
AB - Many proteobacteria possess LuxR solos which are quorum sensing LuxR-type regulators that are not paired with a cognate LuxI-type synthase. LuxR solos have been implicated in intraspecies, interspecies, and interkingdom communication by sensing endogenous and exogenous acyl-homoserine lactones (AHLs) as well as non-AHL signals. LuxR solos are likely to play a major role in microbiome formation, shaping, and maintenance through many different cell-cell signaling mechanisms. This review intends to assess the different types and discuss the possible functional roles of the widespread family of LuxR solo regulators. In addition, an analysis of LuxR solo types and variability among the totality of publicly available proteobacterial genomes is presented. This highlights the importance of these proteins and will encourage scientists to mobilize and study them in order to increase our knowledge of novel cell-cell mechanisms that drive bacterial interactions in the context of complex bacterial communities.
KW - AHLs
KW - LuxR solos
KW - cell-cell interaction
KW - microbial communities
KW - proteobacteria
KW - quorum sensing
UR - http://www.scopus.com/inward/record.url?scp=85156199469&partnerID=8YFLogxK
U2 - 10.1128/msystems.01039-22
DO - 10.1128/msystems.01039-22
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C2 - 36802056
AN - SCOPUS:85156199469
SN - 2379-5077
VL - 8
JO - mSystems
JF - mSystems
IS - 2
ER -