Cell death in mammalian development

C. Penaloza, S. Orlanski, Y. Ye, T. Entezari-Zaher, M. Javdan, Zahra Zakeri*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

During embryogenesis there is an exquisite orchestration of cellular division, movement, differentiation, and death. Cell death is one of the most important aspects of organization of the developing embryo, as alteration in timing, level, or pattern of cell death can lead to developmental anomalies. Cell death shapes the embryo and defines the eventual functions of the organs. Cells die using different paths; understanding which path a dying cell takes helps us define the signals that regulate the fate of the cell. Our understanding of cell death in development stems from a number of observations indicating genetic regulation of the death process: With today's increased knowledge of the pathways of cell death and the identification of the genes whose products regulate the pathways we know that, although elimination of some of these gene produtcs has no developmental phenotype, alteration of several others has profound effects. In this review we discuss the types and distributions of cell death seen in developing mammalian embryos as well as the gene products that may regulate the process.

Original languageAmerican English
Pages (from-to)184-196
Number of pages13
JournalCurrent Pharmaceutical Design
Volume14
Issue number2
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Apoptosis
  • Autophagy
  • Embryonic development
  • Necrosis
  • Programmed cell death

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