TY - JOUR
T1 - Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis
AU - Yanai, Joseph
AU - Vatury, Ori
AU - Slotkin, Theodore A.
PY - 2002
Y1 - 2002
N2 - A wide variety of drugs and chemicals elicit neurobehavioral teratogenesis. Surprisingly, however, despite the obvious differences among unrelated compounds, the behavioral outcomes often display striking similarities, such as cognitive and attentional deficits. Recent studies of drugs of abuse (heroin, nicotine, barbiturates) and environmental toxins (environmental tobacco smoke, pesticides, metals) suggest that, regardless of the originating mechanism for perturbation of brain development, disparate neuroteratogens converge downstream on common families of alterations, characterized by changes in the expression and/or activity of the cell-signaling molecules that are essential to neuronal differentiation and synaptic communication. Identification of these common targets may help in the design of pharmacologic interventions that, administered in adulthood, can reverse the impact of exposure to neurobehavioral teratogens.
AB - A wide variety of drugs and chemicals elicit neurobehavioral teratogenesis. Surprisingly, however, despite the obvious differences among unrelated compounds, the behavioral outcomes often display striking similarities, such as cognitive and attentional deficits. Recent studies of drugs of abuse (heroin, nicotine, barbiturates) and environmental toxins (environmental tobacco smoke, pesticides, metals) suggest that, regardless of the originating mechanism for perturbation of brain development, disparate neuroteratogens converge downstream on common families of alterations, characterized by changes in the expression and/or activity of the cell-signaling molecules that are essential to neuronal differentiation and synaptic communication. Identification of these common targets may help in the design of pharmacologic interventions that, administered in adulthood, can reverse the impact of exposure to neurobehavioral teratogens.
KW - Acetylcholine
KW - Adenylyl cyclase
KW - Brain development
KW - Chlorpyrifos
KW - Cholinergic receptors
KW - Cyclic AMP
KW - Heroin
KW - Muscarinic receptors
KW - Nicotine protein kinase C (PKC)
KW - β-adrenergic receptors
UR - http://www.scopus.com/inward/record.url?scp=0036295541&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2002.tb04188.x
DO - 10.1111/j.1749-6632.2002.tb04188.x
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 12105122
AN - SCOPUS:0036295541
SN - 0077-8923
VL - 965
SP - 473
EP - 478
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -