Cell substrate adhesiveness in S49 mouse lymphoma

Jacob Hochman; Aviva Katz; Efrat Levy; Shmuela Eshel

doi:10.1016/0309-1651(80)90198-8

Cell substrate adhesiveness in S49 mouse lymphoma

Jacob Hochman^*
, Aviva Katz
, Efrat Levy
, Shmuela Eshel

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new variant subline was selected from S49 mouse lymphoma cells grown in suspension culture. These cells, designated S49-Adh, demonstrate increased adhesiveness to their substratum. This, in turn, allows them to grow as a monolayer. Once a dense monolayer is formed, daughter cells develop as a suspension borne population while still retaining their substrate adhesiveness. Cell substrate adhesiveness is a stable genetic trait insofar as submitting S49-Adh cells to both extended periods of in vitro cultivation in culture medium, or in vivo selection through passage in nude mice didn't change their substrate-adhesive phenotype.

Original language	English
Pages (from-to)	953-959
Number of pages	7
Journal	Cell Biology International Reports
Volume	4
Issue number	10
DOIs	https://doi.org/10.1016/0309-1651(80)90198-8
State	Published - 1980

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/0309-1651(80)90198-8

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title = "Cell substrate adhesiveness in S49 mouse lymphoma",

abstract = "A new variant subline was selected from S49 mouse lymphoma cells grown in suspension culture. These cells, designated S49-Adh, demonstrate increased adhesiveness to their substratum. This, in turn, allows them to grow as a monolayer. Once a dense monolayer is formed, daughter cells develop as a suspension borne population while still retaining their substrate adhesiveness. Cell substrate adhesiveness is a stable genetic trait insofar as submitting S49-Adh cells to both extended periods of in vitro cultivation in culture medium, or in vivo selection through passage in nude mice didn't change their substrate-adhesive phenotype.",

author = "Jacob Hochman and Aviva Katz and Efrat Levy and Shmuela Eshel",

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AU - Levy, Efrat

AU - Eshel, Shmuela

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AB - A new variant subline was selected from S49 mouse lymphoma cells grown in suspension culture. These cells, designated S49-Adh, demonstrate increased adhesiveness to their substratum. This, in turn, allows them to grow as a monolayer. Once a dense monolayer is formed, daughter cells develop as a suspension borne population while still retaining their substrate adhesiveness. Cell substrate adhesiveness is a stable genetic trait insofar as submitting S49-Adh cells to both extended periods of in vitro cultivation in culture medium, or in vivo selection through passage in nude mice didn't change their substrate-adhesive phenotype.

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Cell substrate adhesiveness in S49 mouse lymphoma

Abstract

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