Cell surface antigens as differentiation markers of the B lymphocyte lineage

R. Laskov, R. Rabinowitz, A. Haimovitz, M. Schlesinger

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this study no inhibitory effect of anti-T and anti-B sera on rosette forming cells (RFC) was found to show complementation. This may indicate that T-RFC represent a special class of cells having both B and T antigenic determinants. This population could possibly originate from the small population of B-like cells found in the thymus. Alternatively, T-RFC may express B-like properties characteristic of activated T cells. It now seems that on activation T lymphocytes may display Fc receptors on their cell surfaces. Moreover, while normal mouse T cells are unaffected by anti-MBLA serum, following activation T cells become sensitive to the cytotoxic effect of this serum. Thus, while distinct lymphocyte subpopulations show a well-defined pattern of reactivity with heterologous antisera, there is a possibility that their reactivity may change as a result of stimuli triggering activation or malignant transformation.

Original languageEnglish
Pages (from-to)767-776
Number of pages10
JournalIsrael Journal of Medical Sciences
Volume13
Issue number8
StatePublished - 1977

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