TY - JOUR
T1 - Cell surface receptors and lymphocyte migration
AU - Schlesinger, M.
PY - 1976
Y1 - 1976
N2 - Lymphocyte subpopulations show a marked specificity in their distribution in various parts of the lymphoid system. It has been suggested that specific localization of lymphocytes depends on the presence of " homing" receptors on their cell surface. The present paper summarizes some of the approaches used in the study of cell surface receptors involved in the migration and localization of lymphocytes. The effect of exposure of lymphocytes to antibodies, enzymes or lectins, on their capacity for localization is described. It is concluded that the experimental procedures employed do not provide conclusive evidence as to the mechanisms of lymphocyte localization, and that the role of homing receptors is still far from clear.
AB - Lymphocyte subpopulations show a marked specificity in their distribution in various parts of the lymphoid system. It has been suggested that specific localization of lymphocytes depends on the presence of " homing" receptors on their cell surface. The present paper summarizes some of the approaches used in the study of cell surface receptors involved in the migration and localization of lymphocytes. The effect of exposure of lymphocytes to antibodies, enzymes or lectins, on their capacity for localization is described. It is concluded that the experimental procedures employed do not provide conclusive evidence as to the mechanisms of lymphocyte localization, and that the role of homing receptors is still far from clear.
UR - http://www.scopus.com/inward/record.url?scp=84907109537&partnerID=8YFLogxK
U2 - 10.3109/08820137609047619
DO - 10.3109/08820137609047619
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C2 - 799617
AN - SCOPUS:84907109537
SN - 0882-0139
VL - 5
SP - 775
EP - 793
JO - Immunological Investigations
JF - Immunological Investigations
IS - 9
ER -