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Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging
Hagit Masika
, Shmuel Ruppo
, Stephen J. Clark
, Marc Jan Bonder
, Ferdinand von Meyenn
, Merav Hecht
,
Shari Orlanski
, Efrat Katsman
, Oriya Vardi-Yaakov
, Abraham Zlotogorski
, Tahel Fachler-Sharp
,
Sharona Elgavish
,
Yuval Dor
, Wolf Reik
,
Tommy Kaplan
*
,
Howard Cedar
*
*
Corresponding author for this work
Department of Microbiology and Molecular Genetics
Department of Developmental Biology and Cancer Research
Faculty of Medicine
The Rachel and Selim Benin School of Engineering and Computer Science
Institute for Medical Research Israel-Canada (IMRIC)
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Keyphrases
Aging
100%
Methylation
100%
CpG Island
100%
Cellular Heterogeneity
100%
Polycomb
100%
Aging Hallmarks
100%
Cellular Aging
60%
DNA Methylation (DNAm)
40%
Pathological Process
20%
Neurodegeneration
20%
Cellular Level
20%
Cell Behavior
20%
Immune Response
20%
Proliferating Cells
20%
Molecular Mechanism
20%
Tumorigenesis
20%
Phenotypic Change
20%
Age-related
20%
CpG Methylation
20%
Traditional Models
20%
Methylation Data
20%
Cellular Tissue
20%
CpG Island Methylation
20%
Differential Gene Expression Analysis
20%
Whole-genome Methylation
20%
Tissue Homeostasis
20%
Biochemistry, Genetics and Molecular Biology
Methylation
100%
CpG Island
100%
DNA Methylation
33%
Homeostasis
16%
Cell Level
16%
Cell Function
16%
Cell Proliferation
16%
Carcinogenesis
16%
Whole Cell
16%
Gene Expression Profiling
16%
Immune Response
16%
Differential Gene Expression
16%
Molecular Mechanism
16%