TY - JOUR
T1 - Cellular changes in the bone marrow of Plasmodium berghei-infected mice
T2 - II. Blast transformation and phagocytosis
AU - Frankenburg, Shoshana
AU - Londner, Mauricio V.
AU - Greenblatt, Charles L.
PY - 1980
Y1 - 1980
N2 - The present work is concerned with early cellular changes occurring during a malaria infection. Blast transformation by lymphoid cells and phagocytosis by adherent cells from the bone marrow was performed, using immune and nonimmune Balb/c mice. Nonadherent bone marrow cells from immune mice show an increased specific lymphoblast transformation. This increase was not observed during a lethal infection (PI). Adherent bone marrow cells were assayed for phagocytosis of parasitized (PE) or normal erythrocytes (NE). Cells from immune mice show an increase in phagocytosis of PE and NE. Cells from PI mice showed a decreased phagocytosis throughout the infection, beginning at Day 1 after challenge.
AB - The present work is concerned with early cellular changes occurring during a malaria infection. Blast transformation by lymphoid cells and phagocytosis by adherent cells from the bone marrow was performed, using immune and nonimmune Balb/c mice. Nonadherent bone marrow cells from immune mice show an increased specific lymphoblast transformation. This increase was not observed during a lethal infection (PI). Adherent bone marrow cells were assayed for phagocytosis of parasitized (PE) or normal erythrocytes (NE). Cells from immune mice show an increase in phagocytosis of PE and NE. Cells from PI mice showed a decreased phagocytosis throughout the infection, beginning at Day 1 after challenge.
UR - http://www.scopus.com/inward/record.url?scp=0018940179&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(80)90149-5
DO - 10.1016/0008-8749(80)90149-5
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C2 - 7000373
AN - SCOPUS:0018940179
SN - 0008-8749
VL - 55
SP - 185
EP - 190
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -
