Cellular interactions of platinum drugs

Ezequiel Wexselblatt, Eylon Yavin, Dan Gibson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

This manuscript represents a critical review of selected topics relating to the cellular interactions of platinum anticancer drugs. The intent is not to provide a comprehensive summary of all the work described in the literature but to raise questions and cast doubts about selected topics regarding the approaches taken towards trying to elucidate the event that happens in cancer cells that were exposed to platinum complexes. The experimental methods used to study the cellular interactions of platinum complexes are reviewed and the significance of the results obtained from such studies is discussed.

Original languageAmerican English
Pages (from-to)75-83
Number of pages9
JournalInorganica Chimica Acta
Volume393
DOIs
StatePublished - 1 Dec 2012

Bibliographical note

Funding Information:
D.G. thanks the Israel Science Foundation for financial support (Grant 1332/10 ).

Keywords

  • Cellular interactions
  • Platinun anti cancer agents

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