Abstract
The antibiotic cycloheximide inhibits protein synthesis in eukaryotic cells. This overall effect is similar to that of T-2 toxin, but the mechanisms of intoxication by these two inhibitors are different. This is shown here by intracerebral injections of mixtures of T-2 toxin and cycloheximide, leading to potentiation of their toxic effects. The histopathology of cerebral intoxication by the two compounds is similar, but after cycloheximide the lesions appear earlier, and repair is faster.
Original language | English |
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Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Toxicology Letters |
Volume | 57 |
Issue number | 1 |
DOIs | |
State | Published - Jun 1991 |
Keywords
- Cerebral toxicities
- Cycloheximide
- LD
- Synergistic effects
- T-2 toxin