Central effects of cycloheximide alone and of its combination with T-2 toxin

Felix Bergmann*, Me'orah Feinmesser, Boris Yagen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The antibiotic cycloheximide inhibits protein synthesis in eukaryotic cells. This overall effect is similar to that of T-2 toxin, but the mechanisms of intoxication by these two inhibitors are different. This is shown here by intracerebral injections of mixtures of T-2 toxin and cycloheximide, leading to potentiation of their toxic effects. The histopathology of cerebral intoxication by the two compounds is similar, but after cycloheximide the lesions appear earlier, and repair is faster.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalToxicology Letters
Volume57
Issue number1
DOIs
StatePublished - Jun 1991

Keywords

  • Cerebral toxicities
  • Cycloheximide
  • LD
  • Synergistic effects
  • T-2 toxin

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