Central venous pressure, arterial pressure and hypovolemia: Their role in adjustment during heat stress

Mara Schochina, Michal Horowitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Central venous (CVP) and systemic pressures (AP) were measured concomitantly with peripheral blood flow (Tt), colonic temperature (Tc) and plasma volume, in heat stressed (40°C) rats, following manipulation of initial plasma volume and following heat acclimation. Under experimental conditions the Tc of controls (C), heat acclimated (AC) and hypovolemic (HV) rats was regulated at 40.0, 39.6 and 40.6°C and heat tolerance was 190, 360 and 81 min with weight loss of 6-7, 3-4 and > 3% respectively. The response of Tt, AP and plasma volume of all groups was similar whereas CVP differed. AP and peripheral vasodilation were maintained until Tc was approximately 42°C (C, HV) s4t°C (AC). At that stage a significant rise in AP was followed by a sharp fall. Tail vasoconstriction preceded the sharp fall in AP. CVP of C rats gradually decreased, HV rats showed a gradual rise and AC rats maintained rather stable CVP. It is suggested that both hyperhermia and hypovolemia are a burden on thermo-regulation. It can also be concluded that the fall in AP utlimately brings about cardiovascular failure.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalJournal of Thermal Biology
Volume14
Issue number3
DOIs
StatePublished - Jul 1989
Externally publishedYes

Keywords

  • central venous pressure
  • Heat acclimation
  • heat stress
  • systemic pressure

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