TY - JOUR
T1 - Central venous pressure, arterial pressure and hypovolemia
T2 - Their role in adjustment during heat stress
AU - Schochina, Mara
AU - Horowitz, Michal
PY - 1989/7
Y1 - 1989/7
N2 - Central venous (CVP) and systemic pressures (AP) were measured concomitantly with peripheral blood flow (Tt), colonic temperature (Tc) and plasma volume, in heat stressed (40°C) rats, following manipulation of initial plasma volume and following heat acclimation. Under experimental conditions the Tc of controls (C), heat acclimated (AC) and hypovolemic (HV) rats was regulated at 40.0, 39.6 and 40.6°C and heat tolerance was 190, 360 and 81 min with weight loss of 6-7, 3-4 and > 3% respectively. The response of Tt, AP and plasma volume of all groups was similar whereas CVP differed. AP and peripheral vasodilation were maintained until Tc was approximately 42°C (C, HV) s4t°C (AC). At that stage a significant rise in AP was followed by a sharp fall. Tail vasoconstriction preceded the sharp fall in AP. CVP of C rats gradually decreased, HV rats showed a gradual rise and AC rats maintained rather stable CVP. It is suggested that both hyperhermia and hypovolemia are a burden on thermo-regulation. It can also be concluded that the fall in AP utlimately brings about cardiovascular failure.
AB - Central venous (CVP) and systemic pressures (AP) were measured concomitantly with peripheral blood flow (Tt), colonic temperature (Tc) and plasma volume, in heat stressed (40°C) rats, following manipulation of initial plasma volume and following heat acclimation. Under experimental conditions the Tc of controls (C), heat acclimated (AC) and hypovolemic (HV) rats was regulated at 40.0, 39.6 and 40.6°C and heat tolerance was 190, 360 and 81 min with weight loss of 6-7, 3-4 and > 3% respectively. The response of Tt, AP and plasma volume of all groups was similar whereas CVP differed. AP and peripheral vasodilation were maintained until Tc was approximately 42°C (C, HV) s4t°C (AC). At that stage a significant rise in AP was followed by a sharp fall. Tail vasoconstriction preceded the sharp fall in AP. CVP of C rats gradually decreased, HV rats showed a gradual rise and AC rats maintained rather stable CVP. It is suggested that both hyperhermia and hypovolemia are a burden on thermo-regulation. It can also be concluded that the fall in AP utlimately brings about cardiovascular failure.
KW - central venous pressure
KW - Heat acclimation
KW - heat stress
KW - systemic pressure
UR - http://www.scopus.com/inward/record.url?scp=0024366560&partnerID=8YFLogxK
U2 - 10.1016/0306-4565(89)90032-6
DO - 10.1016/0306-4565(89)90032-6
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AN - SCOPUS:0024366560
SN - 0306-4565
VL - 14
SP - 109
EP - 113
JO - Journal of Thermal Biology
JF - Journal of Thermal Biology
IS - 3
ER -