Centrifugal activity in afferent C-fibers influences the spontaneous afferent barrage generated in nerve-end neuromas

Marshall Devor; Ronald Dubner

doi:10.1016/0006-8993(88)90901-8

Centrifugal activity in afferent C-fibers influences the spontaneous afferent barrage generated in nerve-end neuromas

Marshall Devor^*, Ronald Dubner

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have investigated the effect of a prolonged, low-frequency impulse barrage on the spontaneous afferent discharge that originates in experimental nerve-end neuromas in the rat sciatic nerve. Centrifugal activity in afferent A-fibers did not affect electrogenesis in the neuroma. When C-fibers were recruited, however, over half of the axons tested were either suppressed or excited. We suggest that these effects resulted from the stimulation-evoked release of neuroactive peptides or related substances from the cut ends of afferent C-fibers.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Brain Research
Volume	446
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90901-8
State	Published - 19 Apr 1988

Keywords

C-fiber
Nerve injury
Nerve pathophysiology
Neuroma
Pain

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10.1016/0006-8993(88)90901-8

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AB - We have investigated the effect of a prolonged, low-frequency impulse barrage on the spontaneous afferent discharge that originates in experimental nerve-end neuromas in the rat sciatic nerve. Centrifugal activity in afferent A-fibers did not affect electrogenesis in the neuroma. When C-fibers were recruited, however, over half of the axons tested were either suppressed or excited. We suggest that these effects resulted from the stimulation-evoked release of neuroactive peptides or related substances from the cut ends of afferent C-fibers.

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KW - Nerve injury

KW - Nerve pathophysiology

KW - Neuroma

KW - Pain

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Centrifugal activity in afferent C-fibers influences the spontaneous afferent barrage generated in nerve-end neuromas

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Keywords

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