Changes in body composition of children with chronic renal failure during growth hormone treatment

Nachum Vaisman; Zvi Zadik; Roland Duchan; Hillary Voet; Dani Lotan; Aharon Drukker

doi:10.1007/BF00865478

Changes in body composition of children with chronic renal failure during growth hormone treatment

Nachum Vaisman^*, Zvi Zadik, Roland Duchan, Hillary Voet, Dani Lotan, Aharon Drukker

^*Corresponding author for this work

Department of Environmental Economics and Management

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Growth hormone (GH) has different known metabolic effects, among which are lipolysis and anabolic action. We have studied the changes in body composition of children with chronic renal failure (CRF) after 1 year of daily treatment with GH. Body fat percentage and fat body mass (FBM) were derived from four site skinfold measurements; lean body mass (LBM) from total body potassium (TBK) and mid-arm muscle circumference (MAMC); bone mineral density (BMD) was measured by dual photon absorptiometry. GH treatment had a positive effect on weight, heigt and MAMC, but no effect on LBM (as reflected by TBK), FBM and BMD. Z-scores were derived in order to compare subjects with a normal population. While no significant change in z-score was noticed for weight, height, MAMC, FBM and BMD, TBK decreased during treatment. We conclude that GH therapy does not ultimately increase LBM in CRF patients compared with other GH-treated groups.

Original language	English
Pages (from-to)	201-204
Number of pages	4
Journal	Pediatric Nephrology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/BF00865478
State	Published - Apr 1994

Keywords

Body composition
Chronic renal failure
Growth hormone

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10.1007/BF00865478

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title = "Changes in body composition of children with chronic renal failure during growth hormone treatment",

abstract = "Growth hormone (GH) has different known metabolic effects, among which are lipolysis and anabolic action. We have studied the changes in body composition of children with chronic renal failure (CRF) after 1 year of daily treatment with GH. Body fat percentage and fat body mass (FBM) were derived from four site skinfold measurements; lean body mass (LBM) from total body potassium (TBK) and mid-arm muscle circumference (MAMC); bone mineral density (BMD) was measured by dual photon absorptiometry. GH treatment had a positive effect on weight, heigt and MAMC, but no effect on LBM (as reflected by TBK), FBM and BMD. Z-scores were derived in order to compare subjects with a normal population. While no significant change in z-score was noticed for weight, height, MAMC, FBM and BMD, TBK decreased during treatment. We conclude that GH therapy does not ultimately increase LBM in CRF patients compared with other GH-treated groups.",

keywords = "Body composition, Chronic renal failure, Growth hormone",

author = "Nachum Vaisman and Zvi Zadik and Roland Duchan and Hillary Voet and Dani Lotan and Aharon Drukker",

year = "1994",

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doi = "10.1007/BF00865478",

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AU - Vaisman, Nachum

AU - Zadik, Zvi

AU - Duchan, Roland

AU - Voet, Hillary

AU - Lotan, Dani

AU - Drukker, Aharon

PY - 1994/4

Y1 - 1994/4

N2 - Growth hormone (GH) has different known metabolic effects, among which are lipolysis and anabolic action. We have studied the changes in body composition of children with chronic renal failure (CRF) after 1 year of daily treatment with GH. Body fat percentage and fat body mass (FBM) were derived from four site skinfold measurements; lean body mass (LBM) from total body potassium (TBK) and mid-arm muscle circumference (MAMC); bone mineral density (BMD) was measured by dual photon absorptiometry. GH treatment had a positive effect on weight, heigt and MAMC, but no effect on LBM (as reflected by TBK), FBM and BMD. Z-scores were derived in order to compare subjects with a normal population. While no significant change in z-score was noticed for weight, height, MAMC, FBM and BMD, TBK decreased during treatment. We conclude that GH therapy does not ultimately increase LBM in CRF patients compared with other GH-treated groups.

AB - Growth hormone (GH) has different known metabolic effects, among which are lipolysis and anabolic action. We have studied the changes in body composition of children with chronic renal failure (CRF) after 1 year of daily treatment with GH. Body fat percentage and fat body mass (FBM) were derived from four site skinfold measurements; lean body mass (LBM) from total body potassium (TBK) and mid-arm muscle circumference (MAMC); bone mineral density (BMD) was measured by dual photon absorptiometry. GH treatment had a positive effect on weight, heigt and MAMC, but no effect on LBM (as reflected by TBK), FBM and BMD. Z-scores were derived in order to compare subjects with a normal population. While no significant change in z-score was noticed for weight, height, MAMC, FBM and BMD, TBK decreased during treatment. We conclude that GH therapy does not ultimately increase LBM in CRF patients compared with other GH-treated groups.

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KW - Chronic renal failure

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Changes in body composition of children with chronic renal failure during growth hormone treatment

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