TY - JOUR
T1 - Changes in daily leptin, ghrelin and adiponectin profiles following a diet with carbohydrates eaten at dinner in obese subjects
AU - Sofer, S.
AU - Eliraz, A.
AU - Kaplan, S.
AU - Voet, H.
AU - Fink, G.
AU - Kima, T.
AU - Madar, Z.
PY - 2013/8
Y1 - 2013/8
N2 - Background and aims: Our recently published randomised clinical trial evaluated the effect of a low-calorie diet with carbohydrates eaten at dinner. This dietary pattern led to lower hunger scores, and better anthropometric, biochemical and inflammatory outcomes compared to a standard low-calorie diet. In the same study, changes in diurnal secretion patterns of leptin, ghrelin and adiponectin were investigated. Methods and results: Seventy-eight police officers (body mass index (BMI)>30) were randomly allocated to experimental (carbohydrates at dinner) or control weight loss diets for 6 months. Sixty-three subjects finished the programme. On days 0, 7, 90 and 180 blood samples and hunger scores were collected every 4h from 8:00 to 20:00. Hormonal profiles were available for 39.The dietary manipulation led to changes in daylight hormonal profiles in the experimental group. Leptin's secretion curve became convex, with a nadir later in the day (significant difference compared to baseline at morning and evening, p=0.023, p=0.021, respectively). Ghrelin's secretion curve became concave, peaking only in the evening hours. Adiponectin's curve was elevated only after the experimental diet (significant difference compared to baseline at afternoon, p=0.044). Conclusions: We propose that a low-calorie diet with carbohydrates eaten at dinner can modulate daytime hormonal profiles. Taken together with our earlier results, we believe this diet regime may prevent mid-day hunger, better support weight loss and improve metabolic outcomes compared to conventional weight loss diets. The trial is registered at controlled-trials.com, ISRCTN37829376, December 2009.
AB - Background and aims: Our recently published randomised clinical trial evaluated the effect of a low-calorie diet with carbohydrates eaten at dinner. This dietary pattern led to lower hunger scores, and better anthropometric, biochemical and inflammatory outcomes compared to a standard low-calorie diet. In the same study, changes in diurnal secretion patterns of leptin, ghrelin and adiponectin were investigated. Methods and results: Seventy-eight police officers (body mass index (BMI)>30) were randomly allocated to experimental (carbohydrates at dinner) or control weight loss diets for 6 months. Sixty-three subjects finished the programme. On days 0, 7, 90 and 180 blood samples and hunger scores were collected every 4h from 8:00 to 20:00. Hormonal profiles were available for 39.The dietary manipulation led to changes in daylight hormonal profiles in the experimental group. Leptin's secretion curve became convex, with a nadir later in the day (significant difference compared to baseline at morning and evening, p=0.023, p=0.021, respectively). Ghrelin's secretion curve became concave, peaking only in the evening hours. Adiponectin's curve was elevated only after the experimental diet (significant difference compared to baseline at afternoon, p=0.044). Conclusions: We propose that a low-calorie diet with carbohydrates eaten at dinner can modulate daytime hormonal profiles. Taken together with our earlier results, we believe this diet regime may prevent mid-day hunger, better support weight loss and improve metabolic outcomes compared to conventional weight loss diets. The trial is registered at controlled-trials.com, ISRCTN37829376, December 2009.
KW - Adiponectin
KW - Carbohydrates
KW - Ghrelin
KW - Hunger
KW - Leptin
KW - Metabolic syndrome
KW - Satiety
UR - http://www.scopus.com/inward/record.url?scp=84880038047&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2012.04.008
DO - 10.1016/j.numecd.2012.04.008
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 22901843
AN - SCOPUS:84880038047
SN - 0939-4753
VL - 23
SP - 744
EP - 750
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 8
ER -