Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation

Shela Gorinstein*, Hanna Leontowicz, Maria Leontowicz, Ryszard Krzeminski, Mikolaj Gralak, Efren Delgado-Licon, Alma Leticia Martinez Ayala, Elena Katrich, Simon Trakhtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

The aim of this investigation was to compare the influence of naringin versus red grapefruit juice on plasma lipid levels and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets. The antioxidant activity of a correlated quantity of red grapefruit juice was higher than that of naringin. Forty-two male Wistar rats were randomly divided into six groups of 7 named control, naringin, grapefruit, Chol, Chol/naringin, and Chol/grapefruit. The rats of the control group were fed basal diet (BD) and 1-2 mL of distilled water. To the BD of the other five groups were added 0.46-0.92 mg of naringin dissolved in 1-2 mL of distilled water (naringin), 1-2 mL of red grapefruit juice (grapefruit), 1% of nonoxidized cholesterol (NOC) and 1-2 mL of distilled water (Chol), 1% of NOC and 0.46-0.92 mg of naringin in 1-2 mL of water (Chol/naringin), and 1% of NOC and 1-2 mL of red grapefruit juice (Chol/grapefruit). After 30 days of different feeding, it was found that diets supplemented with red grapefruit juice and to a lesser degree with naringin improved the plasma lipid levels mainly in rats fed cholesterol and increased the plasma antioxidant activity. In conclusion, naringin is a powerful plasma lipid lowering and plasma antioxidant activity increasing flavonone. However, fresh red grapefruit is preferable than naringin: it more effectively influences plasma lipid levels and plasma antioxidant activity and, therefore, could be used as a valuable supplement for disease-preventing diets.

Original languageEnglish
Pages (from-to)3223-3228
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume53
Issue number8
DOIs
StatePublished - 20 Apr 2005

Keywords

  • Antioxidant activity
  • Naringin
  • Plasma lipids
  • Rats
  • Red grapefruit

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