TY - JOUR
T1 - Changes in the level of soluble CD-2 molecules in the serum of HIV-infected individuals.
AU - Schlesinger, M.
AU - Afik, O.
AU - Loves, O.
AU - Maayan, S.
AU - Rabinowitz, R.
PY - 1990
Y1 - 1990
N2 - It has been shown previously that the level of soluble CD-2 determinants (E-receptors) is elevated in the serum of patients with various immunodeficiency states. The aim of the present preliminary study was to determine the level of soluble CD-2 in the sera of individuals infected with human immunodeficiency virus (HIV), in order to assess the contribution of soluble CD-2 molecules to the immunological deterioration of these patients. The serum CD-2 concentration was determined by an enzyme-linked immunosorbent assay, using a monoclonal CD-2 antibody. Considerable levels of CD-2 were detected in the sera of 15.9% of 63 normal controls tested, with a mean absorbance at 492 nm of 0.154 +/- 0.033. In contrast, in none of the 13 asymptomatic HIV-infected individuals tested could soluble CD-2 be detected (mean absorbance of 0.00093 +/- 0.0048). Elevated concentrations of CD-2 were found in the sera of 3 of 12 patients tested who were suffering from acquired immunodeficiency syndrome (AIDS). Thus, following HIV infection there is an initial phase of reduction of soluble CD-2, probably reflecting diminished T-cell activation. Thereafter, in some AIDS patients episodes of T-cell destruction seem to be correlated with the release of CD-2 molecules into the serum.
AB - It has been shown previously that the level of soluble CD-2 determinants (E-receptors) is elevated in the serum of patients with various immunodeficiency states. The aim of the present preliminary study was to determine the level of soluble CD-2 in the sera of individuals infected with human immunodeficiency virus (HIV), in order to assess the contribution of soluble CD-2 molecules to the immunological deterioration of these patients. The serum CD-2 concentration was determined by an enzyme-linked immunosorbent assay, using a monoclonal CD-2 antibody. Considerable levels of CD-2 were detected in the sera of 15.9% of 63 normal controls tested, with a mean absorbance at 492 nm of 0.154 +/- 0.033. In contrast, in none of the 13 asymptomatic HIV-infected individuals tested could soluble CD-2 be detected (mean absorbance of 0.00093 +/- 0.0048). Elevated concentrations of CD-2 were found in the sera of 3 of 12 patients tested who were suffering from acquired immunodeficiency syndrome (AIDS). Thus, following HIV infection there is an initial phase of reduction of soluble CD-2, probably reflecting diminished T-cell activation. Thereafter, in some AIDS patients episodes of T-cell destruction seem to be correlated with the release of CD-2 molecules into the serum.
UR - http://www.scopus.com/inward/record.url?scp=0025147896&partnerID=8YFLogxK
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C2 - 1974825
AN - SCOPUS:0025147896
SN - 0361-090X
VL - 14
SP - 347
EP - 351
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
IS - 3
ER -