Characterisation of the antibacterial effect of polyethyleneimine nanoparticles in relation to particle distribution in resin composite

Dana Kesler Shvero, Nathan Zatlsman, Ronen Hazan, Ervin I. Weiss, Nurit Beyth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objectives: To characterise the antibacterial effect of resin composite incorporating crosslinked quaternised polyethyleneimine (QPEI) nanoparticles in relation to their distribution in the bulk material. Methods: The antibacterial effect of resin composite incorporating QPEI nanoparticle was tested against various oral pathogens, including Enterococcus faecalis, Streptococcus mutans, Actinomyces viscousus, Lactobacilus casei and whole saliva. Nanoparticle distribution in the modified resin composite was assessed using X-ray photoelectron spectroscopy (XPS). Additionally, the degree of conversion was recorded. Results: Total bacterial inhibition was detected against all the tested pathogens following direct contact with the outer surface of the modified resin composite. Similarly, the inner surface of the modified resin composite caused total inhibition. Electron microscope images showed bacterial death. XPS revealed surface I-ions on both the outer and the inner surfaces of the modified composite. No I-ions were detected in the unmodified composite. Nanoparticle distribution was higher on the inner surface of the modified composite. The composite's degree of conversion was unaffected by nanoparticle addition. Conclusions: QPEI nanoparticles represent a new generation of antibacterial nanoparticles which are highly promising in preventing bacterial recontamination when restoring teeth.

Original languageAmerican English
Pages (from-to)287-294
Number of pages8
JournalJournal of Dentistry
Volume43
Issue number2
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

Keywords

  • Composite resin
  • Electron microscope
  • Enterococcous faecalis
  • Quaternary ammonium
  • Saliva
  • XPS

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