Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study

Tamir Shragai*, Moshe E. Gatt, Adir Shaulov, Eirini Katodritou, Theodora Triantafyllou, Noa Lavi, Anastasia Pouli, Anastasia Sioni, Iuliana Vaxman, Miri Zektser, Chezi Ganzel, Noam Benyamini, Svetlana Trestman, Tomer Ziv-Baran, Yasmin Adam, Yael C. Cohen, Irit Avivi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.

Original languageAmerican English
Article number106498
JournalLeukemia Research
Volume101
DOIs
StatePublished - Feb 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • Anemia
  • Myeloma

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