Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Ariel Kenig; Yonatan Oster; Ronit Cohen-Poradosu; Klaris Reisenberg; Anat Wieder-Finesod; Mirit Hershman-Sarafov; Ilana Oren; Gabriel Weber; Ron Dagan; Gili Regev-Yochay; Jacob Strahilevitz

doi:10.1007/s10096-022-04500-w

Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Ariel Kenig, Yonatan Oster, Ronit Cohen-Poradosu, Klaris Reisenberg, Anat Wieder-Finesod, Mirit Hershman-Sarafov, Ilana Oren, Gabriel Weber, Ron Dagan, Gili Regev-Yochay, Jacob Strahilevitz^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

Original language	English
Pages (from-to)	1365-1370
Number of pages	6
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	41
Issue number	11
DOIs	https://doi.org/10.1007/s10096-022-04500-w
State	Published - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

Endovascular infections
Infective endocarditis
Invasive pneumococcal disease
Streptococcuspneumoniae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10096-022-04500-w

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Kenig, A., Oster, Y., Cohen-Poradosu, R., Reisenberg, K., Wieder-Finesod, A., Hershman-Sarafov, M., Oren, I., Weber, G., Dagan, R., Regev-Yochay, G., & Strahilevitz, J. (2022). Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study. European Journal of Clinical Microbiology and Infectious Diseases, 41(11), 1365-1370. https://doi.org/10.1007/s10096-022-04500-w

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abstract = "In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.",

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doi = "10.1007/s10096-022-04500-w",

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Kenig, A, Oster, Y, Cohen-Poradosu, R, Reisenberg, K, Wieder-Finesod, A, Hershman-Sarafov, M, Oren, I, Weber, G, Dagan, R, Regev-Yochay, G & Strahilevitz, J 2022, 'Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study', European Journal of Clinical Microbiology and Infectious Diseases, vol. 41, no. 11, pp. 1365-1370. https://doi.org/10.1007/s10096-022-04500-w

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AU - Oster, Yonatan

AU - Cohen-Poradosu, Ronit

AU - Reisenberg, Klaris

AU - Wieder-Finesod, Anat

AU - Hershman-Sarafov, Mirit

AU - Oren, Ilana

AU - Weber, Gabriel

AU - Dagan, Ron

AU - Regev-Yochay, Gili

AU - Strahilevitz, Jacob

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N2 - In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

AB - In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

KW - Endovascular infections

KW - Infective endocarditis

KW - Invasive pneumococcal disease

KW - Streptococcuspneumoniae

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Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Abstract

Bibliographical note

Keywords

UN SDGs

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