Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Ariel Kenig, Yonatan Oster, Ronit Cohen-Poradosu, Klaris Reisenberg, Anat Wieder-Finesod, Mirit Hershman-Sarafov, Ilana Oren, Gabriel Weber, Ron Dagan, Gili Regev-Yochay, Jacob Strahilevitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

Original languageAmerican English
Pages (from-to)1365-1370
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume41
Issue number11
DOIs
StatePublished - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Endovascular infections
  • Infective endocarditis
  • Invasive pneumococcal disease
  • Streptococcuspneumoniae

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