TY - JOUR
T1 - Characterization and mixed infections of three strains of vaccinia virus
T2 - Wild type, IBT resistant and IBT dependent mutants
AU - Katz, E.
AU - Margalith, E.
AU - Winer, B.
AU - Lazar, A.
PY - 1973
Y1 - 1973
N2 - The characteristics of IBT dependent (IBT(D)) and IBT resistant (IBT(R)) mutants of vaccinia virus were compared with those of the wild type (wt) strain. The mutants did not differ from the wild type strain by their sedimentation in sucrose gradients. Minor differences in the polypeptide composition of the virus particles and in the neutralization of the three virus strains by anti vaccinia human immunoglobulin were observed. Mixed infections of the viruses in HeLa cells enabled the growth of the strains under their unfavourable conditions (wt in the presence of IBT and IBT(D) in the absence of IBT).
AB - The characteristics of IBT dependent (IBT(D)) and IBT resistant (IBT(R)) mutants of vaccinia virus were compared with those of the wild type (wt) strain. The mutants did not differ from the wild type strain by their sedimentation in sucrose gradients. Minor differences in the polypeptide composition of the virus particles and in the neutralization of the three virus strains by anti vaccinia human immunoglobulin were observed. Mixed infections of the viruses in HeLa cells enabled the growth of the strains under their unfavourable conditions (wt in the presence of IBT and IBT(D) in the absence of IBT).
UR - http://www.scopus.com/inward/record.url?scp=0015899047&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-21-3-469
DO - 10.1099/0022-1317-21-3-469
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C2 - 4763970
AN - SCOPUS:0015899047
SN - 0022-1317
VL - 21
SP - 469
EP - 475
JO - Journal of General Virology
JF - Journal of General Virology
IS - 3
ER -