Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Charles S. Swindell; Julia M. Heerding; Nancy E. Krauss; Susan B. Horwitz; Israel Ringel

doi:10.1016/S0960-894X(01)80527-8

Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Charles S. Swindell^*
, Julia M. Heerding
, Nancy E. Krauss
, Susan B. Horwitz
, Israel Ringel

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.

Original language	English
Pages (from-to)	1531-1536
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(01)80527-8
State	Published - 23 Jun 1994

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abstract = "Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.",

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AU - Swindell, Charles S.

AU - Heerding, Julia M.

AU - Krauss, Nancy E.

AU - Horwitz, Susan B.

AU - Ringel, Israel

PY - 1994/6/23

Y1 - 1994/6/23

N2 - Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.

AB - Two series of taxol analogs with various N-acyl groups on 3′-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly acitivities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3′-phenylisoserine series was significantly more active than the isoserine series.

UR - https://www.scopus.com/pages/publications/0028283518

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Abstract

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