Chemical and Mossbauer spectroscopic evidence that iron-containing concanavalin A is a ferritin

J. Yariv, A. J. KalbGilboa, J. R. Helliwell, N. Z. Papiz, E. R. Bauminger, I. Nowik

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5 Scopus citations

Abstract

We report here the preparation of iron-containing concanavalin A. It has a protein-to-iron ratio of 2.0, and the iron compound it contains is particulate with an average diameter of 85 Å. Iron-containing concanavalin A interacts reversibly with dextran and with methyl α-D-glucoside. The molecular basis of these findings is discussed and a possible mechanism suggested where one of the molecular forms of concanavalin A has the structure of an apoferritin into which iron is deposited in the form of ferrihydrite.

Original languageEnglish
Pages (from-to)13508-13510
Number of pages3
JournalJournal of Biological Chemistry
Volume263
Issue number27
StatePublished - 1988
Externally publishedYes

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