Chemical and Photochemical-Driven Dissipative Fe3+/Fe2+-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation

Roberto Baretta; Gilad Davidson-Rozenfeld; Vitaly Gutkin; Marco Frasconi; Itamar Willner

doi:10.1021/jacs.4c00625

Chemical and Photochemical-Driven Dissipative Fe³⁺/Fe²⁺-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation

Roberto Baretta
, Gilad Davidson-Rozenfeld
, Vitaly Gutkin
, Marco Frasconi^*
, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A Fe³⁺-ion cross-linked carboxymethyl cellulose, Fe³⁺-CMC, redox-active gel exhibiting dissipative, transient stiffness properties is introduced. Chemical or photosensitized reduction of the higher-stiffness Fe³⁺-CMC to the lower-stiffness Fe²⁺-CMC gel, accompanied by the aerobic reoxidation of the Fe²⁺-CMC matrix, leads to the dissipative, transient stiffness, functional matrix. The light-induced, temporal, transient release of a load (Texas red dextran) and the light-triggered, transient mechanical bending of a poly-N-isopropylacrylamide (p-NIPAM)/Fe³⁺-CMC bilayer construct are introduced, thus demonstrating the potential use of the dissipative Fe³⁺-CMC gel for controlled drug release or soft robotic applications.

Original language	English
Pages (from-to)	9957-9966
Number of pages	10
Journal	Journal of the American Chemical Society
Volume	146
Issue number	14
DOIs	https://doi.org/10.1021/jacs.4c00625
State	Published - 10 Apr 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society

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10.1021/jacs.4c00625

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Baretta, R., Davidson-Rozenfeld, G., Gutkin, V., Frasconi, M., & Willner, I. (2024). Chemical and Photochemical-Driven Dissipative Fe³⁺/Fe²⁺-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation. Journal of the American Chemical Society, 146(14), 9957-9966. https://doi.org/10.1021/jacs.4c00625

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title = "Chemical and Photochemical-Driven Dissipative Fe3+/Fe2+-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation",

abstract = "A Fe3+-ion cross-linked carboxymethyl cellulose, Fe3+-CMC, redox-active gel exhibiting dissipative, transient stiffness properties is introduced. Chemical or photosensitized reduction of the higher-stiffness Fe3+-CMC to the lower-stiffness Fe2+-CMC gel, accompanied by the aerobic reoxidation of the Fe2+-CMC matrix, leads to the dissipative, transient stiffness, functional matrix. The light-induced, temporal, transient release of a load (Texas red dextran) and the light-triggered, transient mechanical bending of a poly-N-isopropylacrylamide (p-NIPAM)/Fe3+-CMC bilayer construct are introduced, thus demonstrating the potential use of the dissipative Fe3+-CMC gel for controlled drug release or soft robotic applications.",

author = "Roberto Baretta and Gilad Davidson-Rozenfeld and Vitaly Gutkin and Marco Frasconi and Itamar Willner",

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Baretta, R, Davidson-Rozenfeld, G, Gutkin, V, Frasconi, M & Willner, I 2024, 'Chemical and Photochemical-Driven Dissipative Fe³⁺/Fe²⁺-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation', Journal of the American Chemical Society, vol. 146, no. 14, pp. 9957-9966. https://doi.org/10.1021/jacs.4c00625

Chemical and Photochemical-Driven Dissipative Fe³⁺/Fe²⁺-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation. / Baretta, Roberto; Davidson-Rozenfeld, Gilad; Gutkin, Vitaly et al.
In: Journal of the American Chemical Society, Vol. 146, No. 14, 10.04.2024, p. 9957-9966.

Research output: Contribution to journal › Article › peer-review

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T1 - Chemical and Photochemical-Driven Dissipative Fe3+/Fe2+-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions

T2 - Applications for Transient Controlled Release and Mechanical Actuation

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AU - Davidson-Rozenfeld, Gilad

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AU - Willner, Itamar

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AB - A Fe3+-ion cross-linked carboxymethyl cellulose, Fe3+-CMC, redox-active gel exhibiting dissipative, transient stiffness properties is introduced. Chemical or photosensitized reduction of the higher-stiffness Fe3+-CMC to the lower-stiffness Fe2+-CMC gel, accompanied by the aerobic reoxidation of the Fe2+-CMC matrix, leads to the dissipative, transient stiffness, functional matrix. The light-induced, temporal, transient release of a load (Texas red dextran) and the light-triggered, transient mechanical bending of a poly-N-isopropylacrylamide (p-NIPAM)/Fe3+-CMC bilayer construct are introduced, thus demonstrating the potential use of the dissipative Fe3+-CMC gel for controlled drug release or soft robotic applications.

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Baretta R, Davidson-Rozenfeld G, Gutkin V, Frasconi M, Willner I. Chemical and Photochemical-Driven Dissipative Fe³⁺/Fe²⁺-Ion Cross-Linked Carboxymethyl Cellulose Gels Operating Under Aerobic Conditions: Applications for Transient Controlled Release and Mechanical Actuation. Journal of the American Chemical Society. 2024 Apr 10;146(14):9957-9966. doi: 10.1021/jacs.4c00625