Chemical Protein Synthesis through Selenocysteine Chemistry

Reem Mousa, Post Sai Reddy, Norman Metanis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Methods for the preparation of small-to-medium-sized proteins by chemical protein synthesis have matured in recent years and proven valuable for protein science. Thanks to the many recent discoveries and developments in the field, proteins up to 300 amino acids can now be prepared in the lab in a matter of days. This technology gives the scientists the flexibility to substitute any atom in the protein sequence; hence synthesis is not constrained to the 20 canonical amino acids. In this Synpacts article we briefly highlight the recent studies on selenocysteine chemistry in the field of chemical protein synthesis. 1 Introduction 2 Selenocysteine in Nature and in Folding Studies 3 Selenocysteine in Protein Synthesis 4 Selenocysteine in Natural Selenoproteins 5 Outlook.

Original languageAmerican English
Article numberst-2017-p0089-sp
Pages (from-to)1389-1393
Number of pages5
Issue number12
StatePublished - 24 Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Georg Thieme Verlag Stuttgart.New York - Synlett.


  • chemical protein synthesis
  • native chemical ligation
  • selenazolidine
  • selenocysteine
  • selenoproteins


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