Chemical Synthesis of Selenoproteins

Rebecca N. Dardashti, Reem Ghadir, Hiba Ghareeb, Orit Weil-Ktorza, Norman Metanis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Chemical protein synthesis is a great approach for accessing challenging proteins, such as post-translationally modified proteins, proteins with unnatural amino acids, and proteins with rare natural amino acids such as selenoproteins. In this book chapter we will discuss the recent advances in the chemical synthesis of selenoproteins, as well as the unique chemistry of selenopeptides and selenoproteins.

Original languageAmerican English
Title of host publicationTotal Chemical Synthesis of Proteins
Publisherwiley
Pages463-488
Number of pages26
ISBN (Electronic)9783527823567
ISBN (Print)9783527346608
DOIs
StatePublished - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 WILEY-VCH GmbH. Published 2021 by WILEY-VCH GmbH.

Keywords

  • Selenocysteine
  • chemical protein synthesis
  • chemoselective reactions
  • native chemical ligation
  • selenopeptides
  • selenoproteins

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