Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3a4 by activating p53

Keyphrases

• Cytochrome P450 3A4 (CYP3A4) 100%
• Cytochrome P450 Enzymes 66%
• Cytochrome P450 3A (CYP3A) 66%
• CYP3A7 66%
• CYP4F2 66%
• CYP4F3 66%
• P450 Enzymes 66%
• Human Liver Cells 66%
• Organic Substrate 33%
• Metabolic Signaling 33%
• Microarray 33%
• Enzymatic Activity 33%
• Novel Functions 33%
• Regulatory Region 33%
• Human Liver 33%
• Cisplatin 33%
• Cytochrome P450 (CYP450) 33%
• P450 33%
• Reporter Gene Assay 33%
• Doxorubicin 33%
• Responsive Element 33%
• HepG2 33%
• Nutlin-3 33%
• Novel Pathways 33%
• Xenobiotics 33%
• Human Donor 33%
• Hydroxylated 33%
• Regulation Mode 33%
• Tumor Site 33%
• Etoposide 33%
• CYP21A2 33%
• CYP19A1 33%
• Primary Liver Cells 33%
• CYP3A5 33%
• Hepatic Response 33%
• HuH6 33%
• CYP24A1 33%
• Chemotherapeutic Regimens 33%
• Chemotherapy Treatment 33%
• CYP4F11 33%
• Systemic Clearance 33%
• CYP4F12 33%
• CYP3A43 33%
• Anticancer Chemotherapeutics 33%

Immunology and Microbiology

• P53 100%
• Liver Cell 27%
• Reporter Gene 9%
• Regulatory Region 9%
• Enzyme Activity 9%
• Xenobiotic 9%