Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis

John W. Rose*, Haya Lorberboum-Galski, David Fitzgerald, Richard McCarron, Kenneth E. Hill, Jeannette J. Townsend, Ira Pastan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

IL2-PE40 is a chimeric protein composed of human interleukin-2 (IL2) genetically fused to a modified form of Pseudomonas exotoxin lacking the cell recognition domain. IL2-PE40 is cytotoxic for IL2 receptor-bearing lymphocytes in culture and can inhibit activation of T cells in vivo. IL2-PE40 can significantly diminish antigen-stimulated proliferation of lymphocytes sensitized to myelin basic protein. Intraperitoneal administration of IL2-PE40 not only markedly inhibits the clinical manifestations of adoptively transferred relapsing experimental allergic encephalomyelitis but also dramatically reduces both inflammation and demyelination characteristic of the disease.

Original languageAmerican English
Pages (from-to)209-217
Number of pages9
JournalJournal of Neuroimmunology
Volume32
Issue number3
DOIs
StatePublished - Jun 1991
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by VA Merit Review Funds and by Research Grant 1929-A-1 from the Multiple Sclerosis Society. We gratefully acknowledge the technical assistance of Craig Kamerath, Greg Gilson, Beckie McLain and Huschang Komeyli.

Funding Information:
Supported by VA Merit Review and Research Grant 1929-A-1 from the National Multiple Sclerosis Society, U.S.A.

Keywords

  • Chimeric cytotoxin
  • Experimental allergic encephalomyelitis
  • Interleukin-2
  • Pseudomonas exotoxin

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