Abstract
CHox E is a novel chicken homeogene that belongs to the H2.0 family of homeodomains. Its homeobox sequence is interrupted by an intron between amino acids 44 and 45. Expression of CHox E during embryogenesis is localized to the central nervous system. The anterior boundary of CHox E expression can initially be localized to rhombomere number 1, later in development this boundary reaches up to the rhombencephalic isthmus. CHox E expression in the spinal cord localizes dorso-ventrally to the dorsal half of the basal plate. CHox E expression is always restricted to the proliferating region, the ventricular zone. As the ventricular zone becomes restricted laterally, so does the CHox E expressing region. Once this region of the ventricular zone ceases to exist, CHox E specific transcripts become undetectable. The site and time of CHox E expression suggest a very early function in the differentiation of the cells derived from that region of the ventricular zone.
| Original language | English |
|---|---|
| Pages (from-to) | 13-24 |
| Number of pages | 12 |
| Journal | Mechanisms of Development |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1991 |
Bibliographical note
Funding Information:We wish to thank Drs. Chaya Kalcheim and Hef-zibah Eyal-Giladi for the discussions regarding the expression studies and Drs. Rebecca Haffner, Gadi Glaser and Joel Yisraeli for critically reading the manuscript. This work was supported by grants from the United States-Israel Binational Science Foundation (86-00014) and grants from the Fund for Basic Research, administered by The Israel Academy of Sciences and Humanities Nos. 241/87 and 179/90 to A.F. and No. 193/87 to Y.G.Z.R. was supported by the Israel Ministry of Research and Development and the National Council for Research and Development.
Keywords
- Central nervous system
- Chicken
- Embryonic development
- Homeobox
- Rhombomeres