CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral restriction in the proliferating region of the spinal cord

Zehava Rangini, Adi Ben-Yehuda, Eli Shapira, Yosef Gruenbaum, Abraham Fainsod*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

CHox E is a novel chicken homeogene that belongs to the H2.0 family of homeodomains. Its homeobox sequence is interrupted by an intron between amino acids 44 and 45. Expression of CHox E during embryogenesis is localized to the central nervous system. The anterior boundary of CHox E expression can initially be localized to rhombomere number 1, later in development this boundary reaches up to the rhombencephalic isthmus. CHox E expression in the spinal cord localizes dorso-ventrally to the dorsal half of the basal plate. CHox E expression is always restricted to the proliferating region, the ventricular zone. As the ventricular zone becomes restricted laterally, so does the CHox E expressing region. Once this region of the ventricular zone ceases to exist, CHox E specific transcripts become undetectable. The site and time of CHox E expression suggest a very early function in the differentiation of the cells derived from that region of the ventricular zone.

Original languageAmerican English
Pages (from-to)13-24
Number of pages12
JournalMechanisms of Development
Volume35
Issue number1
DOIs
StatePublished - Aug 1991

Bibliographical note

Funding Information:
We wish to thank Drs. Chaya Kalcheim and Hef-zibah Eyal-Giladi for the discussions regarding the expression studies and Drs. Rebecca Haffner, Gadi Glaser and Joel Yisraeli for critically reading the manuscript. This work was supported by grants from the United States-Israel Binational Science Foundation (86-00014) and grants from the Fund for Basic Research, administered by The Israel Academy of Sciences and Humanities Nos. 241/87 and 179/90 to A.F. and No. 193/87 to Y.G.Z.R. was supported by the Israel Ministry of Research and Development and the National Council for Research and Development.

Keywords

  • Central nervous system
  • Chicken
  • Embryonic development
  • Homeobox
  • Rhombomeres

Fingerprint

Dive into the research topics of 'CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral restriction in the proliferating region of the spinal cord'. Together they form a unique fingerprint.

Cite this