Chromatin in embryonic stem cell neuronal differentiation

Eran Meshorer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Chromatin, the basic regulatory unit of the eukaryotic genetic material, is controlled by epigenetic mechanisms including histone modifications, histone variants, DNA methylation and chromatin remodeling. Cellular differentiation involves large changes in gene expression concomitant with alterations in genome organization and chromatin structure. Such changes are particularly evident in self-renewing pluripotent embryonic stem cells, which begin, in terms of cell fate, as a tabula rasa, and through the process of differentiation, acquire distinct identities. Here I describe the changes in chromatin that accompany neuronal differentiation, particularly of embryonic stem cells, and discuss how chromatin serves as the master regulator of cellular destiny.

Original languageAmerican English
Pages (from-to)311-319
Number of pages9
JournalHistology and Histopathology
Issue number1-3
StatePublished - Jan 2007


  • Chromatin
  • DNA
  • Development
  • Differentiation
  • Embrionic stem cells
  • Histones
  • Neuron


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