TY - JOUR
T1 - Chromatin in embryonic stem cell neuronal differentiation
AU - Meshorer, Eran
PY - 2007/1
Y1 - 2007/1
N2 - Chromatin, the basic regulatory unit of the eukaryotic genetic material, is controlled by epigenetic mechanisms including histone modifications, histone variants, DNA methylation and chromatin remodeling. Cellular differentiation involves large changes in gene expression concomitant with alterations in genome organization and chromatin structure. Such changes are particularly evident in self-renewing pluripotent embryonic stem cells, which begin, in terms of cell fate, as a tabula rasa, and through the process of differentiation, acquire distinct identities. Here I describe the changes in chromatin that accompany neuronal differentiation, particularly of embryonic stem cells, and discuss how chromatin serves as the master regulator of cellular destiny.
AB - Chromatin, the basic regulatory unit of the eukaryotic genetic material, is controlled by epigenetic mechanisms including histone modifications, histone variants, DNA methylation and chromatin remodeling. Cellular differentiation involves large changes in gene expression concomitant with alterations in genome organization and chromatin structure. Such changes are particularly evident in self-renewing pluripotent embryonic stem cells, which begin, in terms of cell fate, as a tabula rasa, and through the process of differentiation, acquire distinct identities. Here I describe the changes in chromatin that accompany neuronal differentiation, particularly of embryonic stem cells, and discuss how chromatin serves as the master regulator of cellular destiny.
KW - Chromatin
KW - DNA
KW - Development
KW - Differentiation
KW - Embrionic stem cells
KW - Histones
KW - Neuron
UR - http://www.scopus.com/inward/record.url?scp=33846330587&partnerID=8YFLogxK
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C2 - 17163405
AN - SCOPUS:33846330587
SN - 0213-3911
VL - 22
SP - 311
EP - 319
JO - Histology and Histopathology
JF - Histology and Histopathology
IS - 1-3
ER -