Chromatin in pluripotent embryonic stem cells and differentiation

Eran Meshorer*, Tom Misteli

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

579 Scopus citations


Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

Original languageAmerican English
Pages (from-to)540-546
Number of pages7
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - 17 Jul 2006
Externally publishedYes

Bibliographical note

Funding Information:
Eran Meshorer and Tom Misteli are at the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. e-mails: [email protected]; [email protected]


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