Chromatin in pluripotent embryonic stem cells and differentiation

Eran Meshorer; Tom Misteli

doi:10.1038/nrm1938

Chromatin in pluripotent embryonic stem cells and differentiation

Eran Meshorer^*, Tom Misteli

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

568 Scopus citations

Abstract

Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

Original language	American English
Pages (from-to)	540-546
Number of pages	7
Journal	Nature Reviews Molecular Cell Biology
Volume	7
Issue number	7
DOIs	https://doi.org/10.1038/nrm1938
State	Published - 17 Jul 2006
Externally published	Yes

Bibliographical note

Funding Information:
Eran Meshorer and Tom Misteli are at the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. e-mails: meshoree@mail.nih.gov; mistelit@mail.nih.gov

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10.1038/nrm1938

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AB - Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.

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Chromatin in pluripotent embryonic stem cells and differentiation

Abstract

Bibliographical note

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