Abstract
Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.
Original language | English |
---|---|
Pages (from-to) | 540-546 |
Number of pages | 7 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - 17 Jul 2006 |
Externally published | Yes |
Bibliographical note
Funding Information:Eran Meshorer and Tom Misteli are at the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. e-mails: [email protected]; [email protected]