Chromatin regulation and transcription factor cooperation in liver cells

Ido Goldstein

doi:10.1002/9781119436812.ch81

Chromatin regulation and transcription factor cooperation in liver cells

Ido Goldstein

Institute of Biochemistry, Food Science and Nutrition

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Liver cells constantly receive a multitude of signals in the form of hormones, cytokines, metabolites, etc. Tremendous advances in the understanding of hepatic gene expression regulation and how it affects hepatic functions have been seen. This chapter summarizes advances in the emerging field of liver genomics focusing on transcription and chromatin genomics as well as on mechanisms of transcription factor (TF) cooperation within the chromatin environment. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF.

Original language	American English
Title of host publication	THE LIVER: BIOLOGY AND PATHOBIOLOGY
Subtitle of host publication	Biology and Pathobiology
Editors	Irwin M. Arias, Harvey J. Alter, James L. Boyer, David E. Cohen, David A. Shafritz, Snorri S. Thorgeirsson, Allan W. Wolkoff
Publisher	John Wiley & Sons, Ltd
Pages	1043-1049
Number of pages	7
Edition	6TH EDITION
ISBN (Electronic)	9781119436812
ISBN (Print)	9781119436829
DOIs	https://doi.org/10.1002/9781119436812.ch81
State	Published - 24 Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.

Keywords

Chromatin genomics
Hepatic gene expression regulation
Liver cells
Protein-protein interaction
Transcription factor

Access to Document

10.1002/9781119436812.ch81

Cite this

Goldstein, I. (2020). Chromatin regulation and transcription factor cooperation in liver cells. In I. M. Arias, H. J. Alter, J. L. Boyer, D. E. Cohen, D. A. Shafritz, S. S. Thorgeirsson, & A. W. Wolkoff (Eds.), THE LIVER: BIOLOGY AND PATHOBIOLOGY: Biology and Pathobiology (6TH EDITION ed., pp. 1043-1049). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781119436812.ch81

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Chromatin regulation and transcription factor cooperation in liver cells. / Goldstein, Ido.
THE LIVER: BIOLOGY AND PATHOBIOLOGY: Biology and Pathobiology. ed. / Irwin M. Arias; Harvey J. Alter; James L. Boyer; David E. Cohen; David A. Shafritz; Snorri S. Thorgeirsson; Allan W. Wolkoff. 6TH EDITION. ed. John Wiley & Sons, Ltd, 2020. p. 1043-1049.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Goldstein, Ido

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N2 - Liver cells constantly receive a multitude of signals in the form of hormones, cytokines, metabolites, etc. Tremendous advances in the understanding of hepatic gene expression regulation and how it affects hepatic functions have been seen. This chapter summarizes advances in the emerging field of liver genomics focusing on transcription and chromatin genomics as well as on mechanisms of transcription factor (TF) cooperation within the chromatin environment. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF.

AB - Liver cells constantly receive a multitude of signals in the form of hormones, cytokines, metabolites, etc. Tremendous advances in the understanding of hepatic gene expression regulation and how it affects hepatic functions have been seen. This chapter summarizes advances in the emerging field of liver genomics focusing on transcription and chromatin genomics as well as on mechanisms of transcription factor (TF) cooperation within the chromatin environment. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF.

KW - Chromatin genomics

KW - Hepatic gene expression regulation

KW - Liver cells

KW - Protein-protein interaction

KW - Transcription factor

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BT - THE LIVER: BIOLOGY AND PATHOBIOLOGY

A2 - Arias, Irwin M.

A2 - Alter, Harvey J.

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PB - John Wiley & Sons, Ltd

ER -

Chromatin regulation and transcription factor cooperation in liver cells

Abstract

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Keywords

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