Chromatin regulation and transcription factor cooperation in liver cells

Liver cells constantly receive a multitude of signals in the form of hormones, cytokines, metabolites, etc. Tremendous advances in the understanding of hepatic gene expression regulation and how it affects hepatic functions have been seen. This chapter summarizes advances in the emerging field of liver genomics focusing on transcription and chromatin genomics as well as on mechanisms of transcription factor (TF) cooperation within the chromatin environment. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF.