Chromatin regulation and transcription factor cooperation in liver cells

Ido Goldstein*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Liver cells constantly receive a multitude of signals in the form of hormones, cytokines, metabolites, etc. Tremendous advances in the understanding of hepatic gene expression regulation and how it affects hepatic functions have been seen. This chapter summarizes advances in the emerging field of liver genomics focusing on transcription and chromatin genomics as well as on mechanisms of transcription factor (TF) cooperation within the chromatin environment. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF. The concept of tethering also requires protein-protein interaction between TFs. However, in tethering, only one TF is bound to DNA while the other is brought to the enhancer region via its interaction with the motif-bound TF.

Original languageAmerican English
Title of host publicationThe Liver
Subtitle of host publicationBiology and Pathobiology
Publisherwiley
Pages1043-1049
Number of pages7
ISBN (Electronic)9781119436812
ISBN (Print)9781119436829
DOIs
StatePublished - 24 Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.

Keywords

  • Chromatin genomics
  • Hepatic gene expression regulation
  • Liver cells
  • Protein-protein interaction
  • Transcription factor

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