Chromosomal organization is shaped by the transcription regulatory network

Ruth Hershberg, Esti Yeger-Lotem, Hanah Margalit*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

60 Scopus citations


Transcription regulation, a key step in the control of gene expression, has been the focus of several large-scale studies; however, little attention has been given to its relationship with the chromosomal arrangement of transcription units. We studied this relationship systematically in Escherichia coli and Saccharomyces cerevisiae using network analysis methods. Our analysis reveals links between transcription regulation and chromosomal organization, suggesting that in both organisms transcription regulation has shaped the organization of transcription units on the chromosome. Differences found between the organisms reflect the inherent differences in transcription regulation between prokaryotes and eukaryotes.

Original languageAmerican English
Pages (from-to)138-142
Number of pages5
JournalTrends in Genetics
Issue number3
StatePublished - Mar 2005

Bibliographical note

Funding Information:
This study was supported by the Israeli Science Foundation, administered by the Israeli Academy of Sciences and Humanities. R.H. and E.Y.-L. are supported by the Yeshaya Horowitz Association through The Center for Complexity Science.


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