TY - JOUR
T1 - Chronic lymphocytic leukemia
T2 - Molecular genetics and animal models
AU - Pekarsky, Y.
AU - Calin, G. A.
AU - Aqeilan, R.
AU - Croce, C. M.
PY - 2005
Y1 - 2005
N2 - Chronic lymphocytic leukemia accounts for almost 30% of all adult leukemia cases in the United States and Western Europe. Although several common genomic abnormalities in CLL have been identified, mutational and functional analysis of corresponding genes so far have not proved their involvement in CLL. Our latest studies demonstrated functional involvement of Tell oncoprotein and microRNA genes in the pathogenesis of CLL. Deregulated expression of Tell in transgenic mice resulted in CLL. These CLL tumors showed abnormalities in expression of murine microRNA genes mmu-mir-15a and mmu-mir-16-1. Interestingly, human homologs of these genes, mir-15a and mir-16-1, located at the chromosome 13q14 are also deleted in human CLL samples. In this review we summarize and discuss these new developments. These recently emerged insights into the molecular mechanisms of CLL will allow for the development of new approaches to treat this disease.
AB - Chronic lymphocytic leukemia accounts for almost 30% of all adult leukemia cases in the United States and Western Europe. Although several common genomic abnormalities in CLL have been identified, mutational and functional analysis of corresponding genes so far have not proved their involvement in CLL. Our latest studies demonstrated functional involvement of Tell oncoprotein and microRNA genes in the pathogenesis of CLL. Deregulated expression of Tell in transgenic mice resulted in CLL. These CLL tumors showed abnormalities in expression of murine microRNA genes mmu-mir-15a and mmu-mir-16-1. Interestingly, human homologs of these genes, mir-15a and mir-16-1, located at the chromosome 13q14 are also deleted in human CLL samples. In this review we summarize and discuss these new developments. These recently emerged insights into the molecular mechanisms of CLL will allow for the development of new approaches to treat this disease.
UR - http://www.scopus.com/inward/record.url?scp=27144548520&partnerID=8YFLogxK
U2 - 10.1007/3-540-29933-5_4
DO - 10.1007/3-540-29933-5_4
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C2 - 16323427
AN - SCOPUS:27144548520
SN - 0070-217X
VL - 294
SP - 51
EP - 70
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
ER -
