TY - JOUR
T1 - Chronic lymphocytic leukemia presenting with extreme hyperleukocytosis and thrombosis of the common femoral vein
AU - Cukierman, Tali
AU - Gatt, Moshe E.
AU - Libster, Dianna
AU - Goldschmidt, Neta
AU - Matzner, Yaacov
PY - 2002
Y1 - 2002
N2 - Very few case reports dealing with chronic lymphocytic leukemia (CLL) and hyperleukocytosis have been reported in the medical literature and none with venous thrombosis as a complication. Here, we describe a 73-year-old woman who presented with newly diagnosed CLL, leukostasis, and hyperleukocytosis (2000 × 10 9/1), affecting the respiratory and nervous system. In addition, she also had deep vein thrombosis (DVT). Although hypercoagulability and thrombosis are well-described phenomena in solid tumors and in myeloproliferative neoplasms, CLL is generally not associated with an acquired coagulopathy. We hypothesize that in our patient the extreme number of circulating lymphocytes resulted in an abnormal accumulation of lymphocytes possibly causing stasis and occlusion of a larger vessel, which resolved after leukopheresis. The patient has since been successfully maintained with chemotherapy. We conclude that leukopheresis should be considered as the therapy of choice in CLL patients presenting with major complications of leukostasis.
AB - Very few case reports dealing with chronic lymphocytic leukemia (CLL) and hyperleukocytosis have been reported in the medical literature and none with venous thrombosis as a complication. Here, we describe a 73-year-old woman who presented with newly diagnosed CLL, leukostasis, and hyperleukocytosis (2000 × 10 9/1), affecting the respiratory and nervous system. In addition, she also had deep vein thrombosis (DVT). Although hypercoagulability and thrombosis are well-described phenomena in solid tumors and in myeloproliferative neoplasms, CLL is generally not associated with an acquired coagulopathy. We hypothesize that in our patient the extreme number of circulating lymphocytes resulted in an abnormal accumulation of lymphocytes possibly causing stasis and occlusion of a larger vessel, which resolved after leukopheresis. The patient has since been successfully maintained with chemotherapy. We conclude that leukopheresis should be considered as the therapy of choice in CLL patients presenting with major complications of leukostasis.
KW - CLL
KW - Chronic lymphocytic leukemia
KW - Extreme hyperleukocytosis
KW - Femoral vein thrombosis
UR - http://www.scopus.com/inward/record.url?scp=0036332904&partnerID=8YFLogxK
U2 - 10.1080/1042819021000006367
DO - 10.1080/1042819021000006367
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C2 - 12685846
AN - SCOPUS:0036332904
SN - 1042-8194
VL - 43
SP - 1865
EP - 1868
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 9
ER -