TY - JOUR
T1 - Chronic Mucocutaneous Candidiasis in Early Life
T2 - Insights Into Immune Mechanisms and Novel Targeted Therapies
AU - Shamriz, Oded
AU - Tal, Yuval
AU - Talmon, Aviv
AU - Nahum, Amit
N1 - Publisher Copyright:
© Copyright © 2020 Shamriz, Tal, Talmon and Nahum.
PY - 2020/10/16
Y1 - 2020/10/16
N2 - Children with chronic mucocutaneous candidiasis (CMC) experience recurrent infections with Candida spp. Moreover, immune dysregulation in the early life of these patients induces various autoimmune diseases and affects normal growth and development. The adaptive and innate immune system components play a significant role in anti-fungal response. This response is mediated through IL-17 production by T helper cells. Inborn errors in IL-17-mediated pathways or Candida spp. sensing molecules are known to cause CMC. In this review, we describe underlying immune mechanisms of monogenic primary immune deficiency disorders known to cause CMC. We will explore insights into current management of these patients and novel available therapies.
AB - Children with chronic mucocutaneous candidiasis (CMC) experience recurrent infections with Candida spp. Moreover, immune dysregulation in the early life of these patients induces various autoimmune diseases and affects normal growth and development. The adaptive and innate immune system components play a significant role in anti-fungal response. This response is mediated through IL-17 production by T helper cells. Inborn errors in IL-17-mediated pathways or Candida spp. sensing molecules are known to cause CMC. In this review, we describe underlying immune mechanisms of monogenic primary immune deficiency disorders known to cause CMC. We will explore insights into current management of these patients and novel available therapies.
KW - autoimmunity
KW - chronic mucocutaneous candidiasis
KW - CMC
KW - immune dysregulation
KW - primary immune deficiency
UR - http://www.scopus.com/inward/record.url?scp=85094667102&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.593289
DO - 10.3389/fimmu.2020.593289
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C2 - 33178226
AN - SCOPUS:85094667102
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 593289
ER -