Chronic ocular hypertension alters local retinal Responsiveness

Ron Ofri*, William W. Dawson, Kimberly Foli, Kirk N. Gelatt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Electrophysiological responses of the retina and visual cortex to a series of grating stimuli (6-768 minutes of arc) were recorded in seven sessions using normal beagles, 21 sessions using beagles afflicted with inherited ocular hypertension, and 12 sessions using rhesus monkeys. A 15° field centred around the animal's area centralis or fovea was used to stimulate the central retina. A 30° field, centred on the same spot, was then used to stimulate the larger area. Two recording series were completed on each animal, with both field sizes presented in each recording session. The first recording took place 30 minutes after and the second 2 hours after the injection of thiamylal sodium. Only the signals from the toroidal 15° of the retina of the hypertensive dogs were remarkably larger during the second recording (p=0.001). No significant differences were found between the two recordings from the retinas of normal dogs or monkeys, nor were there any significant differences between the two recordings from above the cortex in any group. Several hypotheses are proposed to explain the basis for the interaction of thiamylal with the more peripheral retinal function in clinically glaucomatous dogs.

Original languageAmerican English
Pages (from-to)502-508
Number of pages7
JournalBritish Journal of Ophthalmology
Volume77
Issue number8
DOIs
StatePublished - 1993
Externally publishedYes

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