Chronic treatment with haloperidol affect the response of the brain to pentobarbital

J. Yanai; C. G. Pick; Carmela Iser-Strenger

doi:10.1016/0028-3908(86)90026-2

Chronic treatment with haloperidol affect the response of the brain to pentobarbital

J. Yanai^*, C. G. Pick, Carmela Iser-Strenger

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Treatment of mice with haloperidol increased the number of dopamine D₂ receptors (B_max). The animals were given 40 or 50 mg of pentobarbital. Animals treated with haloperidol had a shorter duration of narcosis induced by pentobarbital than the controls, suggesting a decreased sensitivity to pentobarbital which was functional (CNS), since the animals treated with haloperidol had higher levels of pentobarbital in the brain upon awakening than the controls. The results suggest that increased B_max reduces the sensitivity of the brain to pentobarbital.

Original language	English
Pages (from-to)	943-945
Number of pages	3
Journal	Neuropharmacology
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/0028-3908(86)90026-2
State	Published - Aug 1986

Keywords

dopamine receptor number
haloperidol
mice narcosis
pentobarbital sensitivity

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10.1016/0028-3908(86)90026-2

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title = "Chronic treatment with haloperidol affect the response of the brain to pentobarbital",

abstract = "Treatment of mice with haloperidol increased the number of dopamine D2 receptors (Bmax). The animals were given 40 or 50 mg of pentobarbital. Animals treated with haloperidol had a shorter duration of narcosis induced by pentobarbital than the controls, suggesting a decreased sensitivity to pentobarbital which was functional (CNS), since the animals treated with haloperidol had higher levels of pentobarbital in the brain upon awakening than the controls. The results suggest that increased Bmax reduces the sensitivity of the brain to pentobarbital.",

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AB - Treatment of mice with haloperidol increased the number of dopamine D2 receptors (Bmax). The animals were given 40 or 50 mg of pentobarbital. Animals treated with haloperidol had a shorter duration of narcosis induced by pentobarbital than the controls, suggesting a decreased sensitivity to pentobarbital which was functional (CNS), since the animals treated with haloperidol had higher levels of pentobarbital in the brain upon awakening than the controls. The results suggest that increased Bmax reduces the sensitivity of the brain to pentobarbital.

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Chronic treatment with haloperidol affect the response of the brain to pentobarbital

Abstract

Keywords

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