Chrono-Gerontology: Integrating Circadian Rhythms and Aging in Stroke Research

Nirit Kara, Chinyere Agbaegbu Iweka, Eran Blacher*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Stroke is a significant public health concern for elderly individuals. However, the majority of pre-clinical studies utilize young and healthy rodents, which may result in failure of candidate therapies in clinical trials. In this brief review/perspective, the complex link between circadian rhythms, aging, innate immunity, and the gut microbiome to ischemic injury onset, progression, and recovery is discussed. Short-chain fatty acids and nicotinamide adenine dinucleotide+ (NAD+) production by the gut microbiome are highlighted as key mechanisms with profound rhythmic behavior, and it is suggested to boost them as prophylactic/therapeutic approaches. Integrating aging, its associated comorbidities, and circadian regulation of physiological processes into stroke research may increase the translational value of pre-clinical studies and help to schedule the optimal time window for existing practices to improve stroke outcome and recovery.

Original languageEnglish
Article number2300048
JournalAdvanced Biology
Volume7
Issue number11
DOIs
StatePublished - Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Advanced Biology published by Wiley-VCH GmbH.

Keywords

  • aging
  • circadian rhythms
  • gut-brain axis
  • microbiome
  • nicotinamide adenine dinucleotide (NAD)
  • short-chain fatty acids
  • stroke

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