TY - JOUR
T1 - Chrono-Gerontology
T2 - Integrating Circadian Rhythms and Aging in Stroke Research
AU - Kara, Nirit
AU - Iweka, Chinyere Agbaegbu
AU - Blacher, Eran
N1 - Publisher Copyright:
© 2023 The Authors. Advanced Biology published by Wiley-VCH GmbH.
PY - 2023/11
Y1 - 2023/11
N2 - Stroke is a significant public health concern for elderly individuals. However, the majority of pre-clinical studies utilize young and healthy rodents, which may result in failure of candidate therapies in clinical trials. In this brief review/perspective, the complex link between circadian rhythms, aging, innate immunity, and the gut microbiome to ischemic injury onset, progression, and recovery is discussed. Short-chain fatty acids and nicotinamide adenine dinucleotide+ (NAD+) production by the gut microbiome are highlighted as key mechanisms with profound rhythmic behavior, and it is suggested to boost them as prophylactic/therapeutic approaches. Integrating aging, its associated comorbidities, and circadian regulation of physiological processes into stroke research may increase the translational value of pre-clinical studies and help to schedule the optimal time window for existing practices to improve stroke outcome and recovery.
AB - Stroke is a significant public health concern for elderly individuals. However, the majority of pre-clinical studies utilize young and healthy rodents, which may result in failure of candidate therapies in clinical trials. In this brief review/perspective, the complex link between circadian rhythms, aging, innate immunity, and the gut microbiome to ischemic injury onset, progression, and recovery is discussed. Short-chain fatty acids and nicotinamide adenine dinucleotide+ (NAD+) production by the gut microbiome are highlighted as key mechanisms with profound rhythmic behavior, and it is suggested to boost them as prophylactic/therapeutic approaches. Integrating aging, its associated comorbidities, and circadian regulation of physiological processes into stroke research may increase the translational value of pre-clinical studies and help to schedule the optimal time window for existing practices to improve stroke outcome and recovery.
KW - aging
KW - circadian rhythms
KW - gut-brain axis
KW - microbiome
KW - nicotinamide adenine dinucleotide (NAD)
KW - short-chain fatty acids
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85163822420&partnerID=8YFLogxK
U2 - 10.1002/adbi.202300048
DO - 10.1002/adbi.202300048
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C2 - 37409422
AN - SCOPUS:85163822420
SN - 2366-7478
VL - 7
JO - Advanced Biology
JF - Advanced Biology
IS - 11
M1 - 2300048
ER -