TY - JOUR
T1 - Chronotherapy of malaria
T2 - Improved efficacy of timed chloroquine treatment of patients with plasmodium falciparum infections
AU - Landau, I.
AU - Lepers, J. P.
AU - Ringwald, P.
AU - Rabarison, P.
AU - Ginsburg, H.
AU - Chabaud, A.
PY - 1992/7
Y1 - 1992/7
N2 - The effect of routine treatment with chloroquine (10 mg/kg on days 1 and 2 and 5 mg/kg on day 3) on parasitaemia and parasitaemic profile of patients infected with Plasmodium falciparum was studied. As with P. vinckei petteri, the mid-term trophozoites of P. falciparum were the most susceptible stages to chloroquine treatment. It is suggested that, in order to diminish the frequency of drug administration and to lower the risks of chemoresistance developing, treatment should be diversified, using the drug which is most effective on the parasite stages present in the peripheral blood.
AB - The effect of routine treatment with chloroquine (10 mg/kg on days 1 and 2 and 5 mg/kg on day 3) on parasitaemia and parasitaemic profile of patients infected with Plasmodium falciparum was studied. As with P. vinckei petteri, the mid-term trophozoites of P. falciparum were the most susceptible stages to chloroquine treatment. It is suggested that, in order to diminish the frequency of drug administration and to lower the risks of chemoresistance developing, treatment should be diversified, using the drug which is most effective on the parasite stages present in the peripheral blood.
UR - http://www.scopus.com/inward/record.url?scp=0026760469&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(92)90224-Z
DO - 10.1016/0035-9203(92)90224-Z
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C2 - 1440807
AN - SCOPUS:0026760469
SN - 0035-9203
VL - 86
SP - 374
EP - 375
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 4
ER -
